Thyroidectomy of intact and castrated rats produced significant reductions in their rates of sebum secretion. Replacement therapy with thyroxine (T4) increased the rate of sebum secretion of the castrated-thyroidectomized rats. Treatment with testosterone propionate also stimulated sebum secretion in castrated-thyroidectomized rats. When given together these two hormones had an additive effect on the rate of sebum secretion.
Thyrotrophic hormone (TSH) stimulated sebum secretion in castrated-hypophysectomized, but not in thyroidectomized rats.
It is concluded that TSH affects sebum secretion through its action on the thyroid, presumably by stimulation of T4 secretion.
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