In a previous paper an attempt was made to minimize the effect of random variations during routine toxicological screening in female rats, by using all the previously accumulated control experiments for comparison (Dikstein, Kaplanski, Koch, Locker & Sulman, 1967). The method is based on comparison of organ weights of the treated animals with computer-drawn curves showing the standard weight of organs as a function of body weight in control animals. This method allows the use of as few as six rats for each treatment and six control rats. The method obviates misinterpretation of body weight changes caused either by the treatment or by uncontrollable changes in experimental conditions. In this communication we describe a method developed for use in male rats.
The basic approach is as follows. Using all the data accumulated in previous control experiments, a regression line between a certain measurable parameter (usually the weight of a specific
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