Exogenous androgen produces permanent acyclic, anovulatory sterility in rats less than 11 days old (Gorski, 1968; Lobl & Gorski, 1969), but not in older females (Huffman, 1941). Androgen exerts its influence at the level of the anterior hypothalamus (Barraclough, 1967; Gorski, 1971) during a 'critical period of hypothalamic differentiation'. Comparative studies on the uptake and distribution of androgen in the hypothalamus at different ages have not previously been performed, although Sherratt, Exley & Rogers (1969), using 4-day-old females, and Alvarez & Ramirez (1970), using groups of 2- to 10-day-old females, have reported that the hypothalamus of neonatal female rats does not show preferential uptake of testosterone as compared with the cerebral cortex.
The purpose of our experiment was to determine whether there is a developmental alteration in the uptake of testosterone by the tissues of normal female rats that may be related to the mechanism of steroid-induced sterility.
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