The development of polyuria and polydipsia in rabbits immunized with vasopressin has been reported by Miller & Moses (1969) and Edwards, Chard, Kitau, Forsling & Landon (1972). The degree of polyuria was reported by Miller & Moses (1969) to be related to the titre of the antiserum. The antigenic nature of argininevasopressin (AVP) and the observed unresponsiveness of certain patients with diabetes insipidus treated with vasopressin have been discussed by Roth, Glick, Klein & Petersen (1966). The present communication reports the development of a syndrome resembling diabetes insipidus of varying severity, in three out of four rabbits actively immunized against AVP, and also indicates that antibody affinity, as well as titre, may be a related factor.
Arginine-vasopressin (A. B. Ferring, Sweden) was conjugated to rabbit serum albumin (RSA) by the method of Goodfriend, Fasman, Kemp & Levine (1966). The final dialysate was diluted with saline to give 0·5 mg AVP—RSA
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