Oestrogen stimulation increases spontaneous activity in laboratory rats and this effect appears to be mediated by the anterior hypothalamic—preoptic region (AH—POA) of the diencephalon (Kennedy, 1964). The present study sought to determine whether the antioestrogenic agent actinomycin-D (Act-D) implanted bilaterally in the AH—POA would antagonize the increase in running produced by exogenous oestrogen.
Thirteen virgin Sprague—Dawley rats (260–355 g) aged 85–125 days were housed in individual, metal activity wheels with attached living cages described elsewhere (Stern & Zwick, 1972). Food and water were available ad libitum. The laboratory was on an artificial 12 h light: 12 h dark cycle. Activity (number of revolutions) was recorded daily. The animals were ovariectomized under methoxyfluorane (Metofane) anaesthesia 14 days before implantation under the same anaesthetic. Records of activity were started 7 days after ovariectomy. Double-walled cannulae were implanted bilaterally in the AH—-POA (anterior 7·5; lateral 1·0; vertical — 1·2; deGroot, 1959). The
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