LIPOLYSIS AND ADENOSINE 3′,5′-CYCLIC MONOPHOSPHATE IN ADIPOSE TISSUE OF THE NEW ZEALAND OBESE MOUSE

in Journal of Endocrinology
Authors:
C. J. LOVELL-SMITH
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and
J. G. T. SNEYD
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DOI:
https://doi.org/10.1677/joe.0.0560001
Volume/Issue:
Volume 56: Issue 1
Article Type:
Research Article
Page Range:
1–11
Online Publication Date:
Jan 1973
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SUMMARY

Isolated fat cells from young New Zealand obese mice (NZO/Bl) showed an impaired rate of glycerol release in response to isoprenaline. Old animals showed an increased rate of glycerol release.

The impaired lipolysis in young animals may be caused by failure of the adenosine 3′,5′-cyclic monophosphate level to rise normally when isolated fat cells are treated with isoprenaline. It is proposed that the impaired lipolysis in young NZO/Bl mice is important in the development of obesity.

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Print ISSN:
0022-0795
Online ISSN:
1479-6805
Page(s):
11
Article Type:
Research Article
Print Publication Date:
01 Jan 1973
Online Publication Date:
Jan 1973