LIPOLYSIS AND ADENOSINE 3′,5′-CYCLIC MONOPHOSPHATE IN ADIPOSE TISSUE OF THE NEW ZEALAND OBESE MOUSE

in Journal of Endocrinology
Authors:
C. J. LOVELL-SMITH
Search for other papers by C. J. LOVELL-SMITH in
Current site
Google Scholar
PubMed
Close
and
J. G. T. SNEYD
Search for other papers by J. G. T. SNEYD in
Current site
Google Scholar
PubMed
Close
Restricted access
Rent on DeepDyve

Sign up for journal news

SUMMARY

Isolated fat cells from young New Zealand obese mice (NZO/Bl) showed an impaired rate of glycerol release in response to isoprenaline. Old animals showed an increased rate of glycerol release.

The impaired lipolysis in young animals may be caused by failure of the adenosine 3′,5′-cyclic monophosphate level to rise normally when isolated fat cells are treated with isoprenaline. It is proposed that the impaired lipolysis in young NZO/Bl mice is important in the development of obesity.

 

  • Collapse
  • Expand