In previous experiments in our laboratory, the dog testis exposed to low doses of X-rays has shown great secretory activity in response to pregnant mare serum within a few days of irradiation, and this effect continues for 30 days or so (Shimizu, Yamashita, Sugihara & Tsuchiyama, 1972). However, it has not been ascertained whether the effect occurs within a few hours of exposure. We now report the response of the testis to human chorionic gonadotrophin (HCG) 1·5 h or 24 h after exposure to 200 R of X-rays. The secretory response was determined by measuring total 17-oxosteroids in spermatic venous blood.
Eighteen adult mongrel dogs (9·0–16·3 kg) were studied. Under pentobarbitone anaesthesia (injected i.v.), X-irradiation of the scrotal area alone was administered to 12 dogs in single doses of 200 R. Radiation was delivered using a 200 kV peak therapy unit (200 kV, 20 mA) through a 0·5 mm copper—0·5
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