It is known that corticotrophin (ACTH) stimulates the conversion of cholesterol into pregnenolone (Hechter & Pincus, 1954; Hall & Young, 1968) and increases 11β-hydroxylase activity (Grant, Symington & Duguid, 1957; Griffiths & Glick, 1966). Recent investigations have shown circadian oscillations of 21- and 11β-hydroxylase activity in normal subjects suggesting that, in vivo and under strictly physiological conditions, ACTH influences hydroxylation at the end stages of cortisol biosynthesis (Molino, Perotti, Marino & Dardanelli, 1971).
The present investigation was done in order to evaluate the effects, in man, of different doses of exogenous ACTH on corticosteroidogenesis as a whole, and particularly on 21- and 11-hydroxylation, during the biosynthesis of cortisol. Ten normal male subjects, 24 to 38 years old and with a normal synchronized sleep—waking cycle, were examined. From each subject, a urine sample was taken in basal conditions and a second sample was taken on the following day, after a
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