It is known that corticotrophin (ACTH) stimulates the conversion of cholesterol into pregnenolone (Hechter & Pincus, 1954; Hall & Young, 1968) and increases 11β-hydroxylase activity (Grant, Symington & Duguid, 1957; Griffiths & Glick, 1966). Recent investigations have shown circadian oscillations of 21- and 11β-hydroxylase activity in normal subjects suggesting that, in vivo and under strictly physiological conditions, ACTH influences hydroxylation at the end stages of cortisol biosynthesis (Molino, Perotti, Marino & Dardanelli, 1971).
The present investigation was done in order to evaluate the effects, in man, of different doses of exogenous ACTH on corticosteroidogenesis as a whole, and particularly on 21- and 11-hydroxylation, during the biosynthesis of cortisol. Ten normal male subjects, 24 to 38 years old and with a normal synchronized sleep—waking cycle, were examined. From each subject, a urine sample was taken in basal conditions and a second sample was taken on the following day, after a
Journal of Endocrinology is committed to supporting researchers in demonstrating the impact of their articles published in the journal.
The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.
More information is on the Reasons to publish page.
Sept 2018 onwards | Past Year | Past 30 Days | |
---|---|---|---|
Full Text Views | 0 | 0 | 0 |
PDF Downloads | 1 | 0 | 0 |