ABSENCE OF THE LUTEOLYTIC EFFECT OF PROLACTIN IN THE PREGNANT RAT AFTER HYPOPHYSECTOMY AND HYSTERECTOMY ON DAY 12

in Journal of Endocrinology
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The luteolytic effect of prolactin in the rat seems to be exerted on corpora lutea (CL) which have lost their capacity to secrete progesterone (Desclin, 1949; Malven, Cousar & Row, 1969). Since pregnant rats show signs of progesterone secretion for about 3 days after hypophysectomy and hysterectomy on day 12 (Rothchild, 1972; Rothchild, Billiar, Kline & Pepe, 1973), it seemed worth while to compare their response to prolactin treatment with that of pseudopregnant rats, in which the same operations cause a rapid cessation of progesterone secretion (Rothchild, 1972; Rothchild et al. 1973).

Regularly cyclic 250 g Holtzman (Sprague—Dawley) rats were made pseudopregnant by mechanical stimulation of the cervix; deciduoma formation was induced in some of these by uterine scratching on day 5 (day 1 = last day of cornified vaginal smears). Pregnant rats had been mated in our laboratory (day 1 = day of insemination). Each rat was hypophysectomized and hysterectomized on

 

      Society for Endocrinology

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