In the mouse the uterus passes through a brief period of sensitivity, during which blastocyst attachment takes place and the decidual cell reaction is initiated, followed by a period of insensitivity when the uterus is hostile to a blastocyst and decidualization cannot be initiated (Psychoyos, 1963; Finn, 1966). These functional states can be correlated with distinct morphological changes in the uterine epithelium and are controlled by the ovarian hormones. In the sensitive state the uterine lumen is closed with interlocking of the microvilli from the luminal surfaces of opposing epithelial cells (1st stage of closure) while insensitivity is characterized by a reorganization of the luminal surfaces with the disappearance of the microvilli and the formation of a very complex channel and close apposition of opposing epithelial cells (2nd stage of closure) (Pollard & Finn, 1972).
Ovariectomized mice can be made sensitive to a decidual stimulus by priming for 3 days
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