EFFECT OF GONADOTROPHINS ON THE SECRETION OF OESTRADIOL-17β AND TESTOSTERONE BY THE RAT TESTIS

in Journal of Endocrinology
Authors:
F. H. DE JONG
Search for other papers by F. H. DE JONG in
Current site
Google Scholar
PubMed
Close
,
A. H. HEY
Search for other papers by A. H. HEY in
Current site
Google Scholar
PubMed
Close
, and
H. J. van der MOLEN
Search for other papers by H. J. van der MOLEN in
Current site
Google Scholar
PubMed
Close
Restricted access
Rent on DeepDyve

Sign up for journal news

SUMMARY

Concentrations of oestradiol-17β and testosterone were estimated in peripheral venous plasma and testicular venous plasma of adult male rats before and after administration of human chorionic gonadotrophin (HCG) or follicle-stimulating hormone (FSH). The concentration of oestradiol-17β in peripheral plasma, as measured with a radioimmunological technique, was 2·0 ± 0·9 (s.d.) pg/ml (n = 12). Peripheral testosterone concentrations were 2·4 ± 1·8 (s.d.) ng/ml (n = 21). Concentrations of oestradiol-17β and testosterone in testicular venous plasma were significantly higher than those in peripheral plasma. After intravenous administration of HCG (100 i.u.), oestradiol-17β and testosterone concentrations in testicular venous plasma increased significantly. After prolonged s.c. administration of HCG (5 days) the concentration of oestradiol-17β in testicular venous plasma did not change significantly, although the concentration of testosterone increased more than ten times. Intravenous administration of HCG after 5 days of pretreatment with HCG caused a significant increase in oestradiol-17β concentrations in testicular venous plasma. The increase in testosterone concentration was not significant under these conditions.

Intravenous administration of FSH did not change oestradiol-17β or testosterone concentrations in testicular venous plasma.

 

  • Collapse
  • Expand