In nine men, spermatic and peripheral venous plasma was collected at operative repair of varicocele or inguinal hernia. The concentrations (ng/100ml plasma ± s.e.m.) of both oestradiol-17β (208 ± 28) and oestrone (36 ± 5) were higher than the corresponding values in peripheral venous blood (oestradiol, 3·2 ± 0·5; oestrone, 7·4 ± 1·5). These results confirm that both oestrogens are secreted directly by the testis.
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