Circulating levels of neurophysin, oxytocin and vasopressin were determined in rats under various physiological conditions using bovine neurophysin as the reference standard. Under resting conditions the mean plasma concentration of immunoreactive neurophysin was 6·2 ± 2·4 ng/ml while oxytocin and vasopressin were undetectable.
Neurophysin and vasopressin were released in response to haemorrhage in Wistar and heterozygous Brattleboro rats; in the homozygous strain haemorrhage resulted in a release of oxytocin and neurophysin. Infusion of 0·1 M-calcium chloride into Wistar rats caused a rise in plasma neurophysin, oxytocin and vasopressin. The half-times for the disappearance from the plasma of arginine-vasopressin and neurophysin in the circulation were 1·6 ± 0·8 (S.D.) and 3·4 ± 0·9 min respectively.
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Online ISSN: 1479-6805
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