Changes in urinary hydroxyproline excretion reflect changes in bone resorption (Rasmussen, 1971). High urinary hydroxyproline excretion occurs in primary hyperparathyroidism and after administration of exogenous parathyroid hormone (Prockop & Kivirikko, 1967). However, the urinary excretion of hydroxyproline is not necessarily raised in uraemic patients despite increased secretion of parathyroid hormone, possibly because of abnormal synthesis or maturation of bone collagen (Dubovsky, Dubovska, Pacovsky & Hrba, 1968; Constantinides, Kostamis, Ktoros & Malamos, 1970; Jaworski, Paulsen, Couture, Posen & Galus, 1972).
An experiment was undertaken to determine whether removing the parathyroid glands would affect the urinary excretion of hydroxyproline by uraemic animals. Male Wistar rats (100–120 g) were sham-operated on (groups A and C) or were made uraemic (groups B and D) by first removing two-thirds of the right kidney by cautery and 1 week later removing the entire left kidney. Animals in groups C and D were parathyroidectomized (PTX) immediately before
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