EFFECTS OF HUMAN CHORIONIC SOMATO-MAMMOTROPHIN AND PORCINE GROWTH HORMONE ON THE WEIGHT OF IMMATURE MOUSE UTERUS AND OVARY AND UPTAKE OF α-AMINOISOBUTYRIC ACID BY THESE ORGANS

in Journal of Endocrinology
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S. BISWAS
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P. HINDOCHA
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The role of human chorionic somato-mammotrophin (HCS), a postulated 'growth hormone of pregnancy', on the transport of nutrients through the placenta needs to be investigated. As a simpler alternative we have studied the effects of HCS on the uptake of [14C]α-aminoisobutyric acid ([14C]AIB) by the immature mouse uterus and ovary. The stimulatory effect of growth hormone (GH) on [14C]AIB uptake by the combined uterus and ovary of the rat has been shown previously (Noal, Riggs, Walker & Christensen, 1957). Mice used were of CSI strain and were 21 to 23 days old. Human chorionic somato-mammotrophin (Nutritional Biochemicals) and GH (Sigma Chemical Co. Ltd) were injected intraperitoneally in 0·1 ml 0·15m-NaCl. Control mice received saline alone. Methods previously described (Rosenberg, Blair & Segal, 1961; Rosenberg, Downing & Segal, 1962) were adapted for estimation of total water content of the tissue, determination of extracellular fluid (ECF) with

 

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