Labelled 17α-hydroxyprogesterone was injected into the umbilical vein of each of two male previable human foetuses at the time of laparotomy. The umbilical circulation remained intact for 3 min after which time the tissues of the foetuses, placentae and cords were removed, extracted and the labelled unconjugated metabolites formed were identified. The mid-pregnancy human foetus has a high capacity for metabolizing 17α-hydroxyprogesterone, forming corticosteroids, C-19 steroids and a variety of reduced and hydroxylated metabolites. Androstenedione and testosterone were isolated from both the foetal adrenals and testes but the older of the two foetuses studied contributed in major part to this synthesis. All the foetal tissues examined showed a remarkable capacity to metabolize 17α-hydroxyprogesterone.
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