FORMATION OF CONJUGATED METABOLITES AFTER INJECTION OF [4-14C]17α-HYDROXYPROGESTERONE INTO THE UMBILICAL VEIN OF THE HUMAN FOETUS AT MID-PREGNANCY

in Journal of Endocrinology
Authors:
W. LING
Search for other papers by W. LING in
Current site
Google Scholar
PubMed
Close
,
J. R. T. COUTTS
Search for other papers by J. R. T. COUTTS in
Current site
Google Scholar
PubMed
Close
,
M. C. MACNAUGHTON
Search for other papers by M. C. MACNAUGHTON in
Current site
Google Scholar
PubMed
Close
, and
S. SOLOMON
Search for other papers by S. SOLOMON in
Current site
Google Scholar
PubMed
Close
Restricted access
Rent on DeepDyve

Sign up for journal news

SUMMARY

After injection of [4-14C]17α-hydroxyprogesterone into the umbilical vein of two male human foetuses at mid-pregnancy a number of steroid conjugates were isolated from the foetal adrenals, liver, intestines and residual tissues, confirming the capacity of the human foetus to conjugate an extensive range of steroid substrates. The conjugated steroids isolated were 17α-hydroxypregnanolone sulphate (liver, intestine), 3β,17α-dihydroxy-5α-pregnan-20-one sulphate (residue), pregnanetriol sulphate (liver, residue), cortisol sulphate (adrenal), pregnanetriol glucosiduronate (liver, residue) and 17α-hydroxypregnanolone glucosiduronate (liver).

 

  • Collapse
  • Expand