The specific action of synthetic thyrotrophin releasing factor (TRF) on the release of thyrotrophin, both in vivo and in vitro, has been established in several species including human subjects (Bowers, Schally, Schalch, Gual, Kastin & Folkers, 1970; Fleischer, Burgus, Vale, Dunn & Guillemin, 1970; Hall, Amos & Garry, 1970; LaBella & Vivian, 1971). In spite of the physiological and chemical evidence that hypothalamic factors may be specific for each of the pituitary hormones, an effect of synthetic TRF on the release of prolactin was recently described in man (Jacobs, Snyder, Wilber, Utiger & Daughaday, 1971), lactating cows (Convey, Tucker, Smith & Zolman, 1972), and in rat somatotrophic-mammotrophic tumour cell cultures (Tashjian, Barowsky & Jensen, 1971).
This study was undertaken to see if synthetic TRF could induce the release of prolactin when injected into intact female rats. Virgin albino rats weighing between 200 and 250 g were used. A solution of
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