In the normal oestrous cycle of the rat, a fluid accumulates in the uterine lumen during proestrus and oestrus. This fluid has an unusually high K+ concentration (Ringler, 1961). The function of the fluid may be important in capacitation of spermatozoa (Austin, 1951) or in sperm transport.
In the present study, administration of oestradiol (1·0 μg/day for 3 days) to ovariectomized rats resulted in an accumulation of fluid in the uterine lumen similar to that described by Ringler (1961). When the dose of oestradiol was increased to 10 μg/day for 3 days, the volume of fluid which accumulated increased and the concentration of K+ also increased to a maximum of 40–45 mequiv./l. The Na+ concentration decreased concomitantly so that the sum of the concentrations of the two ions remained constant and suggested the presence of an exchange mechanism.
An attempt was made to alter the Na+ and K+ concentrations with
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