Numerous studies have provided evidence that intricate interactions exist among foetoplacental, ovarian and adrenal functions during pregnancy in rats (see Petropoulos, 1973). Such interactions are shown by: maternal adrenal hypertrophy and hyperfunction in pregnancy; longer survival of gravid than non-gravid rats after adrenalectomy; placental metabolic disturbances (Petropoulos, 1973), foetal adrenal hypertrophy, and decreased litter size and neonatal body weight after maternal adrenalectomy; premature placental ageing and foetal resorption after corticosterone administration to normal pregnant rats, but full-term, successful pregnancies in protein-deprived gravid rats given corticosterone. A question as yet unanswered, however, is whether the placenta secretes corticosterone into the general corticosterone pool of the gravid rat; this question led us to consider plasma corticosterone profiles of normal pregnancy, as well as the role of ovarian, adrenal and placental function in shaping these profiles. To accomplish these ends we used the scheme of classical endocrinological experiment, following the design of a
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