The enzymes, Δ45α-reductase, 3α- and 3β-hydroxysteroid oxidoreductases are present in the immature rat testis and account for its ability to produce saturated steroids from androstenedione and testosterone (Stylianou, Forchielli & Dorfman, 1961; Nayfeh, Barefoot & Baggett, 1966). Progesterone is converted to saturated C19-steroids by the immature rat testis in vitro (Steinberger & Ficher, 1969). It is assumed that androstenedione and testosterone are obligatory intermediates in their synthesis. Since it is known that 4,5-unsaturated C21-steroids are reduced in the rat testis (Bell, Vinson & Lacy, 1971) it was of interest to know whether saturated C21-steroids might also be precursors of saturated C19-steroids. To test this possibility [4-14C]5α-pregnane-3,20-dione was incubated in vitro with testicular tissue from sexually immature rats, and C19-steroids were sought among the products.
[4-14C]5α-Pregnane-3,20-dione was prepared by hydrogenation of 16 nmol (1 μCi)
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