Coffey, Ichinose, Shimazaki & Williams (1968) and Ritter (1966) have demonstrated that 2 weeks after castration the concentration of ATP in the rat ventral prostate remains unchanged from normal levels but that 1 h after testosterone treatment dramatic reductions in ATP concentrations are observed. The cellular site of testosterone action upon ATP metabolism is unknown. In a complex tissue such as the prostate it is difficult, if not impossible, to examine separately the biochemistry of the epithelium and muscle; this can be effectively surmounted using the guinea-pig seminal vesicle. From this, a relatively pure preparation of epithelium can be obtained, and the biochemical sensitivity of these two cell lines may be compared. It is the purpose of this work to examine the effects of castration and testosterone replacement upon the levels of ATP in the epithelium and muscle of the guinea-pig seminal vesicle as well as in the prostate.
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