It has been established in animals that anterior pituitary hormones control their own secretion by regulating at a hypothalamic level the release of their hypothalamic factors (Motta, Fraschini & Martini, 1969). If a negative 'short-feedback' of thyroid-stimulating hormone (TSH) on the hypothalamus exists in man, the high plasma TSH levels of untreated primary hypothyroidism should fall markedly after the administration of bovine TSH which shares the biological, but not the immunological, properties of human TSH. This report describes the effects of bovine TSH on human plasma TSH (H-TSH) levels in patients with primary hypothyroidism.
Twenty-seven patients with untreated primary hypothyroidism were studied, of whom 20 had been treated with 131I and four by subtotal thyroidectomy for thyrotoxicosis. The remaining three patients had spontaneous primary hypothyroidism. The diagnosis of primary hypothyroidism was made on clinical grounds and on the basis of a low serum protein-bound iodine (< 3·8 μg/100 ml),
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Online ISSN: 1479-6805
Print ISSN: 0022-0795
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