Stewart (1971) showed that mice of the Peru strain produce [8-lysine]-vasopressin rather than [8-arginine]-vasopressin which is found in other strains of mice and is the usual form of the neurohypophysial hormone in mammals other than the Suina (Ferguson & Heller, 1965). Most mammals are more sensitive to [8-arginine]-vasopressin than [8-lysine]-vasopressin as an antidiuretic hormone (Sawyer, Chan & van Dyke, 1962); but in pigs [8-lysine]-vasopressin is nearly as potent as [8-arginine]-vasopressin (Ferguson & Heller, 1965), indicating some co-adaptation of the renal receptors and the chemical structure of the hormone. It was therefore decided to assess the relative sensitivity of Peru and CBA/FaCam mice to [8-arginine]-vasopressin and [8-lysine]-vasopressin.
Although stomach-loading of conscious Peru mice will induce a rapid water diuresis (Stewart, 1968), this is inhibited by anaesthesia and operational stress. Two bioassay methods using conscious animals have therefore been developed and used on CBA/FaCam and Peru adult male mice. In one method,
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