BREAKDOWN OF [3H]OXYTOCIN BY RAT TISSUES IN VITRO

in Journal of Endocrinology
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SUMMARY

Tissue uptake of oxytocin by rat mammary gland, uterus, heart and skeletal muscle was demonstrated by incubation of these tissues with 3H-labelled oxytocin. Chromatography of tissue extracts showed that some breakdown of oxytocin had occurred after only 30 s. However, in all cases there was no breakdown of oxytocin in the corresponding incubation medium. This indicated that the breakdown of oxytocin occurred within the tissues.

 

      Society for Endocrinology

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