In female rats neonatal treatment with oestrogen induces persistent vaginal cornification and sterility at maturity (Takewaki, 1962). Recently, we found that the pituitary secretion of prolactin, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in such oestrogenized female rats is permanently altered (Nagasawa, Yanai, Kikuyama & Mori, 1973). No data are available, however, on the effect of pituitary hormones, administered neonatally, on the secretory activity of the pituitary in adult rats. In the present experiment the pituitary secretion of prolactin, LH and FSH was measured in adult female rats treated neonatally with prolactin.
Virgin female Sprague—Dawley rats were used. Half the females in each litter were given a daily subcutaneous injection of bovine prolactin (NIH-P-B2) dissolved in 0·25–1·0 ml 0·9% NaCl solution (pH 8) for 20 days beginning on day 0 of age. The dose of prolactin was 0·5 mg for the first 5 days, 1·0 mg for the second 5
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