EFFECTS OF THE ADMINISTRATION OF THIOURACIL TO DOGS

in Journal of Endocrinology
Author:
GERTRUDE E. GLOCK
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It has been previously shown [Glock, 1944] that rats fed thiourea or thiouracil develop adrenal cortical deficiency in the terminal stages. Gross histological changes were observed in the adrenal cortex and growth of the animals could be restored by injecting adrenal cortex extract. To obtain confirmatory evidence and to determine whether this effect was the result of functional thyroidectomy or of a direct action of the goitrogenic drug on the adrenal cortex, it was decided to use dogs as experimental animals. The degree of hypothyroidism could also be followed more easily than in rats.

METHODS

General diet

The dogs were fed on a diet consisting of dog biscuits 53 %, meat 38 %, whole milk powder 5 %, dried yeast 2 % and cod-liver oil 2 %, moistened with sufficient water to bind the ingredients. They were fed once daily in the morning. Water was allowed ad lib. The dogs receiving thiouracil had 0·1 % of

 

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