GOITROGENIC EFFECT OF AMINOTHIAZOLE AND REACTIONS OF THYMUS AND LYMPHOID TISSUE

in Journal of Endocrinology
Author:
CH. GRÉGOIRE
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The reports on the influence of thyroidectomy on the thymus are controversial. Involution of the organ has long been recorded in most observations and confirmed in recent papers: Marine [1926], Marine, Manley & Baumann [1924], Carrière, Gineste & Laine in young animals only [1937], Carrière, Morel & Gineste [1938], Chiodi [1938], personal unpublished results [1938], Reinhardt & Wainman [1942].

On the other hand, thymic hypertrophy or absence of direct reaction has been pointed out by Kiyonari [1929]. According to Selye [1937], thyroidectomy as such does not cause involution of the thymus and lymphatic organs, but facilitates involution in sensitizing the organism to alarming stimuli: rats killed 2–4 days after thyroidectomy almost invariably have small thymuses, probably as a result of surgical trauma. Within 14 days the thymus reassumes normal size.

These assumptions of Selye are not in agreement with the findings of Chiodi [1938] and of Carrière et al. [1937],

 

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