THE 'DIABETOGENIC' ACTIVITY OF GROWTH-PROMOTING PITUITARY EXTRACTS IN RATS

in Journal of Endocrinology
Authors:
J. H. GAARENSTROOM
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J. HUBLÉ
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S. E. DE JONGH
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Dogs that are treated with pituitary extracts develop a kind of diabetes which manifests itself first in glycosuria, and later in damage to the pancreatic islets. This reaction, however, is not found in all kinds of animals. There may well be species differences in sensitivity, and if these originate in the islets of Langerhans the sensitivity of the more resistant animals (e.g. of rats), might be enhanced by measures to diminish the activity of the pancreas. Marx, Anderson, Fong & Evans [1943] removed large parts of the pancreas of rats to this end, and found that the slight glycosuria which they obtained became more severe when the animals were subsequently treated with a hypophyseal preparation. As a highly purified growth-promoting extract was used for this purpose, the experiments once more indicate a relation between the growth-promoting and the 'diabetogenic' functions of the hypophysis.

METHOD

The effect of growth-promoting preparations has

 

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