Earlier observations had shown that a number of steroid hormones, especially those with testoid ('androgenic') activity, not only restore the atrophic kidney of castrates to normal, but can actually stimulate renal growth above the normal level and thus exhibit a true 'renotrophic action' [Selye, 1939a, b]. The literature concerning this newly discovered effect has become quite extensive [Beland, Masson & Selye, 1944; Crabtree, 1941; Feyel, 1943; Fried, 1943; Gallien, 1940; von Gasche & Meier, 1941; Kochakian, 1941, 1944a, b, c, 1946a, b, 1947a, b; Kochakian & Stettner, 1948; Korenchevsky & Hall, 1941a, b; Laqueur, 1942; Lattimer, 1942; Le Compte, 1944; Longley, 1942; Ludden, Krueger & Wright, 1941; MacKay, 1940; Masson & Beland, 1943; Oster, 1945; Pierre, 1942; Reynolds, 1943; Schilling & Laqueur, 1942; Selye, 1941a; Selye & Albert, 1942 a, b; Selye & Friedman, 1941; Selye & Stone, 1947; Shay, Gershon-Cohen, Paschkis & Fels,
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