It has been shown that antibody production in cold-blooded animals is inhibited at temperatures in the region of 10° C. [Bisset, 1947a, b]. It is mainly the release of antibodies into the serum which is thus prevented; low temperatures have much less effect upon the acquisition of the potential for antibody formation, during the process of immunization [Bisset, 1948]. Frogs immunized at 8° C. do not produce antibodies so long as they remain at that temperature, but commence to do so when the temperature is raised to 20° C., although the titre may not be as high as if the original immunization had been conducted at 20° C. Similarly, frogs immunized at 20° C. cease to produce antibodies when cooled to 8° C., and regain the power when the temperature is restored.
It is apparent that this phenomenon provides a means by which the processes of acquiring immunity and
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