It is now recognized that quantitative and qualitative measurements of urinary neutral 17-ketosteroids may be of clinical significance in the diagnosis of certain pituitary and adrenal disorders, but whereas there is much information concerning the normal values in adults, the normal range of excretion in childhood (Table 1) is less accurately known. While the figures obtained by Nathanson, Towne & Aub [1941] are appreciably higher than those of Talbot, Butler & MacLachlan [1940], the more recent figures of Hain [1947] agree with those of Talbot. The present investigation describes the results obtained in a series of normal children within the age group 2–12 years.
Callow & Crooke [1944] suggested that dehydroisoandrosterone was excreted in greatly increased amounts in cases of adrenal cortical tumour and considered that the presence of an abnormally high proportion of this substance in the urine might be of fundamental diagnostic value. Methods for the quantitative isolation
Journal of Endocrinology is committed to supporting researchers in demonstrating the impact of their articles published in the journal.
The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.
More information is on the Reasons to publish page.
Sept 2018 onwards | Past Year | Past 30 Days | |
---|---|---|---|
Full Text Views | 10 | 0 | 0 |
PDF Downloads | 2 | 1 | 0 |