THE URINARY EXCRETION OF NEUTRAL 17-KETOSTEROIDS IN CHILDHOOD

in Journal of Endocrinology
Authors:
MARY E. WOOD
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C. H. GRAY
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It is now recognized that quantitative and qualitative measurements of urinary neutral 17-ketosteroids may be of clinical significance in the diagnosis of certain pituitary and adrenal disorders, but whereas there is much information concerning the normal values in adults, the normal range of excretion in childhood (Table 1) is less accurately known. While the figures obtained by Nathanson, Towne & Aub [1941] are appreciably higher than those of Talbot, Butler & MacLachlan [1940], the more recent figures of Hain [1947] agree with those of Talbot. The present investigation describes the results obtained in a series of normal children within the age group 2–12 years.

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Callow & Crooke [1944] suggested that dehydroisoandrosterone was excreted in greatly increased amounts in cases of adrenal cortical tumour and considered that the presence of an abnormally high proportion of this substance in the urine might be of fundamental diagnostic value. Methods for the quantitative isolation

 

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