The importance of the relationship of the thyroid gland to growth has long attracted attention. With the ever-increasing use of thyroid-inhibiting agents to treat human hyperthyroidism, the possibility of adversely affecting the growth and development of the foetus by thiouracil administered to the mother has focused attention on this particular aspect of the problem. Hughes [1944], Williams [1944], Goldsmith, Gordon & Charipper [1944, 1945] and Freiesleben & Kjerulf-Jensen [1946, 1947] have shown clearly that various thiouracils can be transferred from the maternal blood across the placenta to the foetus in the rat. Hughes [1944], Goldsmith et al. [1944] and Freiesleben & Kjerulf-Jensen [1946, 1947] also confirm the findings of Williams, Kay & Jandorf [1944] and Williams, Weinglass, Bissell & Peters [1944] that these drugs are secreted into the milk by the mammary glands in the rat and the human. Thus, characteristic effects on the thyroid glands and interference with growth
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