Previous work [White, Heinbecker & Rolf, 1942; Pickford & Ritchie, 1944] has shown that hypophysectomized dogs cannot produce a normal water diuresis. After hypophysectomy the maximum rate of urine flow in diuresis due to the ingestion of a standard volume of water is 50 % or less of the normal, and the time taken to excrete the water may be as long as 24 hr. instead of 2½–3 hr. The glomerular filtration rate (GFR), renal plasma flow (RPF) and maximum tubular excretion as measured by inulin or creatinine and diodone clearances are markedly below normal. The condition is permanent and is present whether the dog has polyuria or a normal 24 hr. urine output. At autopsy the kidneys are microscopically normal.
The object of the observations described below was to find whether the results of this work on dogs are applicable to man, i.e. whether disease of the anterior lobe of
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