The urinary 11-oxygenation index has been measured throughout pregnancy in 25 women. The index rose steadily throughout pregnancy. At about 35 weeks gestation it rose rapidly, reached a peak just before parturition and rapidly fell to normal thereafter. Statistical analysis indicated that there might be differences in the index levels between women who delivered spontaneously and women in whom induction was necessary. It is suggested that this rise in the index reflects a foetal adrenocortical enzyme inactivity, leading to an increased secretion of cortisol precursors into the maternal circulation at term, which may be involved in the processes of parturition.
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