Whole body metabolic clearance rates (MCR) and splanchnic, hepatic and renal clearance rates of cortisol were estimated in six shorn sheep under control conditions. The measurements were repeated in the same animals when they were exposed to a cold, wet environment while they were maintaining a normal rectal temperature and again when they became hypothermic, their mean final rectal temperature ( ~ 36 °C) having been reduced approximately 2–3 °C below the control range. The quantitative changes in MCR that occurred during cold stress were found to be associated with corresponding changes in splanchnic and renal clearance rates. Increases in plasma cortisol concentrations up to 50 μg/1 were accompanied by proportional increases in rates of splanchnic blood flow and cortisol clearance. When cortisol concentrations rose above 50 μg/1 in hypothermic animals the MCR values tended to fall because of reductions in hepatic and renal blood flow; very large increases in plasma cortisol concentrations then resulted from comparatively small increases in production rate.
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