The uptake of technetium as pertechnetate by the thyroid is currently accepted as a useful index of thyroid function (Alexander, Harden & Shimmins, 1969). Although Pitt-Rivers & Trotter (1953) have shown thyroidal radioiodide concentration in the colloid using autoradiography, the intrathyroidal site of technetium concentration has not been determined previously.
In this paper, we report the results of autoradiographic studies with [99Tc] pertechnetate in rat thyroid using a method which prevents diffusion of soluble radionuclides until exposure to the autoradiographic emulsion is completed.
Four Sprague—Dawley albino adult male rats were used initially. Two rats received aminotriazole (0·1%) in their drinking water for 3 weeks before the study; the other two rats were on a normal diet. [99Tc]pertechnetate (300 μCi) was administered i.p. to each animal and after 1 h one animal in each group received 10 mg sodium perchlorate by the same route. Ninety minutes
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