Administration of testosterone propionate (TP) to neonatal female rats induces a syndrome of sterility, characterized by acyclicity and anovulation (Barraclough & Gorski, 1961; Gorski, 1966; Lobi & Gorski, 1969). This study shows the ability of the uterus of androgenized female rats to respond to oestradiol by change in weight and by formation of specific oestrogen-induced proteins (IP) (Barnea & Gorski, 1970).
To study the response of the uterus to oestradiol, groups of 15 normal dioestrous and 15 androgenized (1·25 mg TP s.c. on postnatal day 3) adult female rats were hemihysterectomized (ipsilateral ovary removed simultaneously) and the excised uterine tissue was cleaned and weighed. These animals were then injected twice daily with 4 μg oestradiol benzoate for 5 days. On the 6th day, all animals were killed and the remaining uterine horn was excised, cleaned and weighed. Another group of nine androgenized and ten oestrous females were bilaterally ovariectomized. Six
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