Plasma corticosterone levels were measured throughout pregnancy and on the first day post partum in the mouse. During the first half of pregnancy plasma corticosterone levels rose from the non-pregnant value of 2·3 μg/100ml to 15·2 μg/100 ml on day 10. During the second half of pregnancy there was a sharp rise, levels reaching a peak of 138·3 μg/100ml on day 16. Following parturition there was a rapid fall to 18·3 μg/100 ml on the morning of the first day post partum. Adrenalectomy on day 15 resulted in an 80% fall in plasma corticosterone levels indicating that most of the steroid was of adrenal origin. The remaining portion of the corticosterone was found to be of foeto-placental origin, and in the chronically adrenalectomized animal this source was capable of maintaining high blood levels of corticosterone (67 μg/100 ml). The foeto-placental unit also provides the main secretory stimulus to the adrenal gland, but the mechanism by which it does this is not understood.
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