Male mouse urine contains an androgen-dependent aversive pheromone which discourages prolonged investigation, by male conspecifics, of an area marked with such urine (Jones & Nowell, 1973a). The source of this pheromone lies in the coagulating glands, whose secretion, when combined with bladder urine, causes avoidance (Jones & Nowell 1973b). The present study describes an attempt to inhibit the release of the aversive pheromone of male mice by treatment with the potent anti-androgen cyproterone acetate. Thus the open-field responses of male mice to the urine of either oil-injected or cyproterone acetate-injected males were compared. Some confirmation of the inhibitory action of cyproterone acetate upon sex accessory organ responses to endogenous androgens was gained by recording the weights of the ventral prostate, preputial and coagulating glands.
Twenty 24-day-old male t.o. albino mice were divided into two groups of ten; the first group received s.c. injections of cyproterone acetate (2 mg/mouse)
Journal of Endocrinology is committed to supporting researchers in demonstrating the impact of their articles published in the journal.
The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.
More information is on the Reasons to publish page.
| Sept 2018 onwards | Past Year | Past 30 Days | |
|---|---|---|---|
| Full Text Views | 1 | 0 | 0 |
| PDF Downloads | 1 | 1 | 0 |
Online ISSN: 1479-6805
Print ISSN: 0022-0795
Strengthening biomedical communities
to advance science and health
CONTACT US
Bioscientifica Ltd | Starling House | 1600 Bristol Parkway North | Bristol BS34 8YU | UK
Bioscientifica Ltd | Registered in England no 3190519
