The effects of NADPH, NADP+, succinate and cyclic AMP on progestational steroid synthesis have been investigated in subcellular fractions of rabbit interstitial tissue. Production of progesterone and 20α-hydroxy-4-pregnen-3-one increased during incubation of mitochondria with NADPH and NADP+ respectively, and an increase in 20α-hydroxy-4-pregnen-3-one was observed after incubation of microsomes with NADP+. No changes in progestational steroid production were observed in individual cell fractions after incubation with cyclic AMP or succinate. However, a small but significant increase in progesterone synthesis occurred in a combined fraction containing mitochondria, microsomes and cytosol when incubated with cyclic AMP.
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