The syndrome of testicular feminization may occur in complete or incomplete forms, the latter being characterized by varying degrees of virilism. In the complete form, plasma concentrations of testosterone and 5α-dihydrotestosterone are usually in or above the normal male range although the metabolic clearance rates of the steroids are similar to those of the normal female and lower than those of the normal male (Tremblay, Kowarski, Park & Migeon, 1972).
The formation in vitro of androstenedione and testosterone by gonads from such subjects has been demonstrated (Griffiths, Grant & Whyte, 1963; Neher & Kahnt, 1966; Charreau & Villee, 1968), but although the formation of 5α-reduced steroids has been inferred (Tremblay et al. 1972), their biosynthesis has not previously been recorded. In view of the changes in steroid 4-ene-5α-reductase activity at puberty in animal testes (Steinberger & Ficher, 1969), the production and metabolism of C19-reduced steroids in gonads from
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