Glucocorticoids have been shown to have an important role in the release, excretion and degradation of catecholamines in the rat (Avakian & Callingham, 1968; Westfall & Osada, 1969; Parvez & Parvez, 1972). Since seasonal changes in adrenocortical as well as monoamine oxidase activities were found in the ground squirrel (Petrović & Janić, 1964; Petrović, Janić, Gripois & Roffi, 1973), it seemed interesting to study the relationship between the adrenal cortex and monoamine oxidase activity in this hibernator during the winter.
Adult male ground squirrels weighing 160–-200 g were housed singly in plastic cages, with wood-chip bedding, in a room at 30 °C to keep them in a normothermic state. They were maintained with daily illumination and given pelleted rat food and water ad libitum. One group was adrenalectomized under ether anaesthesia and examined 10 days later. The second was adrenalectomized and treated with 1 mg hydrocortisone (Galenika)/100 g body weight
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