Recently a single hypothalamic hormone, termed luteinizing hormone releasing hormone (LH-RH), capable of releasing luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary has been chemically characterized and synthesized (Matsuo, Arimura, Nair & Schally, 1971; Matsuo, Baba, Nair, Arimura & Schally, 1971) and has been shown to be biologically active in several species (Schally, Arimura & Kastin, 1973). Initial attempts to demonstrate LH-RH action in 4-day cyclic mice treated with sodium barbitone in pro-oestrus were unsuccessful because barbitone did not consistently block ovulation (R. G. Gosden, unpublished results). In this report we demonstrate the action of LH-RH in adult female mice as shown by the induction of ovulation and the increase of serum LH.
Young virgin (8–14 weeks) CFLP mice (Carworth Europe) were injected with 3 i.u. pregnant mare serum gonadotrophin (Intervet) i.p. at 16.00–17.00 h without reference to the stage of the oestrous cycle. Approximately 44 h later
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