There is increased evidence that serotonin (5-HT) plays an inhibitory role in the control of ovulation. Increased hypothalamic 5-HT and intraventricular injection of the drug block ovulation (Kordon, 1969; Schneider & McCann, 1970; Domanski, Przekop & Skubiszewski, 1972; Labhsetwar, 1972; Mess, Treintini & Tima, 1972). Serotonin injected in vivo blocks spontaneous ovulation (Labhsetwar, 1971) and reduces hypothalamic but not cortical oxygen consumption in vitro (Campos & Ladosky, 1972; Ladosky & Campos, 1972).
Baumgarten, Björklund, Lachenmayer, Nobin & Stenevi (1971) introduced 5,6-dihydroxytryptamine (5,6-DHT) for long-lasting selective depletion of brain 5-HT. Due to these properties 5,6-DHT is a better tool than p-chlorophenylalanine previously used (Labhsetwar, 1972). In these experiments 50 μg 5,6-DHT were infused into the third ventricle of intact male and female rats and gonadectomized animals. All were bled 10 days later and luteinizing hormone (LH) was assayed by radioimmunoassay. Results were compared with those from saline-perfused intact and gonadectomized
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