RADIOIMMUNOASSAY OF PITUITARY AND PLASMA PROLACTIN DURING THE OESTROUS CYCLE IN MICE

in Journal of Endocrinology
Authors:
REIKO YANAI
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HIROSHI NAGASAWA
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Recently, several investigators have reported that a peak concentration of serum prolactin occurs during the late afternoon of pro-oestrus in rats (Meites & Clemens, 1972; Meites, Lu, Wuttke, Welsch, Nagasawa & Quadri, 1972). Also Ieiri, Nobunaga & Yamamoto (1972) found that the synthesis and release of prolactin by rat anterior pituitaries in vitro increased markedly from the afternoon of pro-oestrus to the afternoon of oestrus. On the other hand, no similar information is available on the pituitary secretion of prolactin during the oestrous cycle in mice. Yanai, Nagasawa, Nobunaga & Yamamoto (1973), using mice killed between 09.30 and 10.00 h, showed that the synthesis and release of prolactin in vitro was highest on the day of dioestrus (the day before pro-oestrus) and lowest on the day of oestrus. In the present communication, we have determined the changes in pituitary and plasma prolactin levels during the oestrous cycle in mice using

 

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