After iodine depletion of mice, the time needed for the bioassay of long-acting thyroid stimulator (LATS) and thyroid-stimulating hormone (TSH) can be shortened to allow the completion of two assays per week. Suppression of mouse TSH with 0·1 μg tri-iodothyronine was necessary in the TSH assay and with 5 μg thyroxine in the LATS assay. These can be administered as a single i.p. injection with the 131I. The response of the assay mice to TSH can be improved by giving theophylline (0·5 mg) just before, with and after the stimulus.
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