Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Headington, Oxford, 0X3 9DU
(Received 24 April 1974)
Progesterone levels in the blood of pregnant sheep increase with increasing number of foetuses and with gestational age (Bassett, Oxborrow, Smith & Thorburn, 1969), and are thought to be reduced as a result of foetal cortisol secretion preceding parturition (Liggins, 1973). Data presented here suggest that β-adrenergic stimulation may also influence placental progesterone production.
Utero-ovarian venous and intra-amniotic catheters were inserted in four pregnant ewes, gestational ages 119–130 days, 3–4 days before experimentation. Jugular venous catheters were inserted on the day of the experiment, which was carried out on the conscious animals. Progesterone, total unconjugated oestrogens (oestrone + oestradiol-17/β + oestradiol-17α) and prostaglandin F were measured in utero-ovarian or jugular venous plasma by specific radioimmunoassays (Flint, Anderson, Patten & Turnbull, 1974). Neither orciprenaline nor salmefamol cross-reacted at concentrations up to the equivalent of
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