I.N.R.A. Theix, 63110 Beaumont, France, and *Department of Animal Physiology and Nutrition, The University of Leeds, Leeds, LS5 3HL, England
(Received 3 May 1974)
It has been demonstrated that histamine injections in guinea-pigs cause peptic ulceration and death from peritonitis secondary to perforation of the ulcer and that the thyroid gland of these animals contains a non-thyroxine factor which regulates gastric HCl secretion (Watman & Nasset, 1949, 1951) and which protects against gastric ulceration. Thus we have investigated the effect of porcine calcitonin (P-CT) given intragastrally on histamine-induced peptic ulcer and gastric HCl secretion in guinea-pigs.
In the first experiment 18 young black and white male (180–200 g) guinea-pigs were used. They were given food and water ad libitum throughout the experiment. Twelve of them were surgically thyroidectomized (TX) (with preservation of the parathyroid glands) 10 days before the beginning of the experiment. These animals were supplemented with thyroxine (T4)
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