*Department of Biochemistry, †Department of Obstetrics and Gynaecology, Program in Reproductive Biology and ‡Department of Pathology, McMaster University, Health Sciences Centre, Hamilton, Ontario, Canada L8S 4J9
(Received 28 May 1974)
Although (−)-trans-Δ9-tetrahydrocannabinol (THC), the major psychoactive constituent of marihuana (Mechoulam & Shani, 1970), has a wide variety of pharmacological actions, little is known about the effects of this compound on endocrine function. Nir, Ayalon, Tsafriri, Cordova & Lindner (1973) demonstrated that administration of THC to pro-oestrous rats resulted in suppression of the pre-ovulatory surge of luteinizing hormone. Kolodny, Masters, Kolodner & Toro (1974) have found depressed plasma testosterone levels in marihuana smokers. Gynaecomastia in chronic marihuana smokers has been reported (Harmon & Aliapoulos, 1972) and intimated to result from an effect of THC on prolactin (PRL) secretion. Since oestradiol-17β benzoate (OB) is known to affect PRL release (Chen & Meites, 1970), the present work was undertaken to examine the hypothesis
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